| First Author | McDuffie M | Year | 1992 |
| Journal | J Immunol | Volume | 148 |
| Issue | 7 | Pages | 2097-102 |
| PubMed ID | 1531997 | Mgi Jnum | J:12668 |
| Mgi Id | MGI:60905 | Doi | 10.4049/jimmunol.148.7.2097 |
| Citation | McDuffie M, et al. (1992) I-E-independent deletion of V beta 17a+ T cells by Mtv-3 from the nonobese diabetic mouse [published erratum appears in J Immunol 1992 Jun 15;149(2):745] [see comments]. J Immunol 148(7):2097-102 |
| abstractText | Analysis of TCR beta-chain V region (V beta) frequency among NOD lymphocytes reveals a profound depletion of V beta 3+ T cells, and a recent study has linked this phenomenon to the Mtv-3 insertion on chromosome 11. When the V beta 17a gene segment is introduced into mice with an nonobese diabetic mouse background, T cells bearing the TCR encoded by this gene segment are also dramatically reduced in frequency. Deletion of V beta 17a+ T cells segregates with deletion of T cells bearing V beta 3 and occurs in the absence of I-E, which had been shown in previous studies to be a major deleting element for V beta 17a+ thymocytes. |
