| First Author | Lane JR | Year | 1992 |
| Journal | J Exp Med | Volume | 175 |
| Issue | 4 | Pages | 1123-9 |
| PubMed ID | 1552283 | Mgi Jnum | J:12677 |
| Mgi Id | MGI:60913 | Doi | 10.1084/jem.175.4.1123 |
| Citation | Lane JR, et al. (1992) Interleukin 1 or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10.A mice. J Exp Med 175(4):1123-9 |
| abstractText | We have previously demonstrated that bacterial lipopolysaccharide (LPS) is capable of promoting Coxsackie B3 (CB3)-induced myocarditis in genetically resistant B10.A mice. Because LPS is known to increase production of various cytokines, we tested CB3-infected, LPS-treated mice for the presence of interleukin 1 (IL-1) and tumor necrosis factor (TNF). We found significantly increased amounts of both cytokines in the sera of CB3/LPS-treated mice compared with animals treated only with LPS. We also found immunohistochemical evidence for local production of these cytokines in the cardiac tissue of CB3/LPS-treated mice. Treatment with IL-1 or TNF alone promoted CB3-induced autoimmune myocarditis in resistant B10.A mice. Myocarditis was also observed when uninfected mice were immunized with syngeneic heart extract in the presence of IL-1 or TNF. |
