| First Author | Sweet A | Year | 1992 |
| Journal | Biochem Med Metab Biol | Volume | 47 |
| Issue | 1 | Pages | 97-102 |
| PubMed ID | 1562359 | Mgi Jnum | J:853 |
| Mgi Id | MGI:49386 | Doi | 10.1016/0885-4505(92)90011-m |
| Citation | Sweet A, et al. (1992) A potential animal model for studying CF heterozygote advantage: genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice. Biochem Med Metab Biol 47(1):97-102 |
| abstractText | We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA/2J than in the C57BL/6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL/6J parental strain while colonic segments from five recombinant inbred B x D lines ranged between the C57BL/6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17. |
