| First Author | Sodhi A | Year | 1992 |
| Journal | Clin Exp Immunol | Volume | 88 |
| Issue | 2 | Pages | 350-5 |
| PubMed ID | 1572101 | Mgi Jnum | J:790 |
| Mgi Id | MGI:49324 | Doi | 10.1111/j.1365-2249.1992.tb03086.x |
| Citation | Sodhi A, et al. (1992) Effect of interferon-gamma priming on the activation of murine peritoneal macrophages to tumouricidal state by cisplatin, IL-1, and tumour necrosis factor (TNF): production of IL-1 and TNF. Clin Exp Immunol 88(2):350-5 |
| abstractText | The effect of interferon-gamma (IFN-gamma) priming of murine peritoneal macrophages on the activation to tumouricidal state by cisplatin, lipopolysaccharide (LPS)-IL-1 and TNF was investigated. Cisplatin-, LPS-, IL-1- or TNF-treated IFN-gamma-primed macrophages showed significantly enhanced tumouricidal activity and binding to tumour cells, compared with unprimed treated or untreated macrophages. Macrophages treated with cisplatin, LPS, IL-1 and TNF produced released and membrane-associated IL-1 and TNF activity which was significantly enhanced after priming with IFN-gamma. These observations suggest the use of IFN-gamma along with these biological response modifiers in designing immunotherapeutic protocols for treatment of malignancy. |
