| First Author | Zwartkruis F | Year | 1992 |
| Journal | Nucleic Acids Res | Volume | 20 |
| Issue | 7 | Pages | 1599-606 |
| PubMed ID | 1349742 | Mgi Jnum | J:566 |
| Mgi Id | MGI:49103 | Doi | 10.1093/nar/20.7.1599 |
| Citation | Zwartkruis F, et al. (1992) The murine Hox-2.4 promoter contains a functional octamer motif. Nucleic Acids Res 20(7):1599-606 |
| abstractText | Like other HOX genes the murine Hox-2.4 gene is thought to be involved in regional specification along the antero-posterior axis. In addition it has been reported to have oncogenic potential. We studied expression Hox-2.4 in murine EC cells and determined the transcription start site. Studies of DNA-protein interactions in the promoter region showed that the Hox-2.4 promoter contains a CCAAT box and a perfect octamer motif, which is capable of binding Oct-factors. Cotransfection of Oct expression vectors influences the transcriptional activity of the promoter, suggesting that the Oct-gene family may be involved in regulating HOX genes. |
