| First Author | Fowlis GA | Year | 1992 |
| Journal | Mamm Genome | Volume | 3 |
| Issue | 4 | Pages | 192-6 |
| PubMed ID | 1611214 | Mgi Jnum | J:1084 |
| Mgi Id | MGI:49616 | Doi | 10.1007/BF00355718 |
| Citation | Fowlis GA, et al. (1992) PCR-analyzed microsatellites of the mouse genome--additional polymorphisms among ten inbred mouse strains. Mamm Genome 3(4):192-6 |
| abstractText | Eighty sequences from the mouse genome database containing microsatellites (simple sequence repeats) have been analyzed for size variation among ten different inbred strains of mice; 62/80 (77.5%) showed polymorphism of at least three alleles. We have been able to detect all the polymorphisms by agarose gel electrophoresis, often running the gels for up to 3 h. Between individual pairs of mouse strains to be used in chromosomal mapping studies in our laboratory, 35-60% polymorphism occurred. There are potentially enough microsatellites within the mouse and human genome to have a marker at every 1-cM distance. This simple approach will, therefore, continue to be useful in genome mapping studies, leading eventually to high-resolution maps of both the mouse and human genomes; this should allow for physical mapping and cloning of specific genes. |
