| First Author | Elder JT | Year | 1992 |
| Journal | Hum Genet | Volume | 89 |
| Issue | 5 | Pages | 487-90 |
| PubMed ID | 1321791 | Mgi Jnum | J:2105 |
| Mgi Id | MGI:50629 | Doi | 10.1007/BF00219171 |
| Citation | Elder JT, et al. (1992) Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization. Hum Genet 89(5):487-90 |
| abstractText | Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human CRABP-II (hCRABP-II) gene (isolated from a human genomic library) to localize hCRABP-II to human chromosome 1 band q21 by fluorescence in situ hybridization. Localization to 1q was confirmed by hybridization of a hCRABP-II cDNA clone against a human-mouse hybrid cell line containing a t(1;6)(q21;q13)) translocation chromosome. The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin. |
