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Publication : Structure of the murine gene encoding apolipoprotein A-I.

First Author  Boyle TP Year  1992
Journal  Gene Volume  117
Issue  2 Pages  243-7
PubMed ID  1639271 Mgi Jnum  J:1669
Mgi Id  MGI:50195 Citation  Boyle TP, et al. (1992) Structure of the murine gene encoding apolipoprotein A-I. Gene 117(2):243-7
abstractText  A 1.6-kb DNA fragment containing the gene encoding apolipoprotein A-I from the mouse, Mus musculus, has been cloned and sequenced. It contains three exons separated by two introns and encodes a secreted polypeptide of 262 amino acids (aa), 238 of which constitute the mature protein. Comparisons with the rat and human proteins indicate moderate levels of shared identity (71 and 66%, respectively), although the overall aa compositions yield proteins with identical pIs (5.4). Kyte-Doolittle analyses of the three proteins indicate that there is no significant difference in the structure of these apolipoproteins.
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