| First Author | Shimamura K | Year | 1992 |
| Journal | Dev Biol | Volume | 152 |
| Issue | 2 | Pages | 242-54 |
| PubMed ID | 1644219 | Mgi Jnum | J:31207 |
| Mgi Id | MGI:78709 | Doi | 10.1016/0012-1606(92)90132-z |
| Citation | Shimamura K, et al. (1992) E-cadherin expression in a particular subset of sensory neurons. Dev Biol 152(2):242-54 |
| abstractText | We found that the dorsal root ganglia (DRG) and trigeminal ganglia of mouse embryos express the E-cadherin cell-cell adhesion molecule and analyzed its expression profile. E-cadherin expression began around Embryonic Day 12 (E12) in these ganglia, thereafter increased, and persisted to the adult stage. This cadherin was expressed by 10 and 30% of DRG neurons in E17 and postnatal animals, respectively, as well as by satellite cells and some Schwann cells. E-cadherin-positive primary sensory fibers terminated only in a narrow region of the dorsal horn of the spinal cord, which was identified as part of lamina II by double-staining for E-cadherin and substance P or somatostatin. This E-cadherin expressing area of the spinal cord extended to part of the trigeminal nucleus in the medulla. These results showed that E-cadherin is expressed in a particular subset of primary sensory neurons which may have specific functional properties. We suggest that this adhesion molecule may play a role in the selective adhesion of sensory neuronal fibers. |
