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Publication : Chromosomal localization of three human D5 dopamine receptor genes.

First Author  Grandy DK Year  1992
Journal  Genomics Volume  13
Issue  4 Pages  968-73
PubMed ID  1387108 Mgi Jnum  J:1692
Mgi Id  MGI:50218 Doi  10.1016/0888-7543(92)90009-h
Citation  Grandy DK, et al. (1992) Chromosomal localization of three human D5 dopamine receptor genes. Genomics 13(4):968-73
abstractText  It is currently thought that genetic predisposition to imbalances in dopaminergic transmission may underlie several neurological disorders, including schizophrenia, manic depression, Tourette syndrome, Parkinson disease, Huntington disease, and alcohol abuse. Originally two receptors, D1 and D2, were thought to account for all of the pharmacological actions of dopamine. However, through homology screening three additional genes, D3, D4, and D5, and two pseudogenes closely related to D5 have been characterized. To begin our genomic and evolutionary analyses of the human D5 dopamine receptor gene and its two pseudogenes, we have mapped each of them to their respective chromosomes. By combining in situ hybridization results with sequence analysis of PCR products from microdissected chromosomes, somatic cell hybrids, and radiation hybrids, we have assigned DRD5 (the locus containing the functional human D5 receptor gene) to chromosome 4p16.1, DRD5P1 (the locus containing D5 pseudogene 1) to chromosome 2p11.1-p11.2, and DRD5P2 (the locus of D5 pseudogene 2) to chromosome 1q21.1.
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