| First Author | Burgoyne PS | Year | 1992 |
| Journal | Cell | Volume | 71 |
| Issue | 3 | Pages | 391-8 |
| PubMed ID | 1423603 | Mgi Jnum | J:3019 |
| Mgi Id | MGI:51535 | Doi | 10.1016/0092-8674(92)90509-b |
| Citation | Burgoyne PS, et al. (1992) Fertility in mice requires X-Y pairing and a Y-chromosomal spermiogenesis gene mapping to the long arm. Cell 71(3):391-8 |
| abstractText | There is accumulating evidence that the mammalian Y chromosome, in addition to its testis-determining function, may have other male limited functions, particularly in spermatogenesis. We have previously shown that the short arm of the mouse Y carries information needed for spermatogonial proliferation. This information, together with the testis-determining gene Sry, is contained within the Y-derived sex reversal factor Sxra. XO males carrying a copy of Sxra attached to the X chromosome are nevertheless sterile owing to an almost complete arrest during the meiotic metaphase stages. Here we show that this meiotic block can be overcome by providing a meiotic pairing partner (with no Y-specific DNA) for the XSxra chromosome. However, this does not restore fertility because the sperm produced all have abnormal heads. It is concluded that the Y-specific region of the mouse Y chromosome long arm includes information essential for the normal development of the sperm head. |
