First Author | Kaupmann K | Year | 1992 |
Journal | Genomics | Volume | 14 |
Issue | 2 | Pages | 488-90 |
PubMed ID | 1427864 | Mgi Jnum | J:2666 |
Mgi Id | MGI:51188 | Doi | 10.1016/s0888-7543(05)80247-2 |
Citation | Kaupmann K, et al. (1992) The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. Genomics 14(2):488-90 |
abstractText | A mouse myotube-derived cDNA encoding the Ca(2+)-dependent cell adhesion molecule M-cadherin was used to study the segregation of the corresponding gene Cdh3 in a mouse interspecific backcross. Cdh3 was found to be unlinked to the N-cadherin gene but linked to the E-cadherin (uvomorulin) locus on chromosome 8 in a region of conserved synteny with human chromosome 16q. The gene order cen-Junb-Um-Tat-(Cdh3/Aprt) was determined. The human homologue CDH3 was mapped to chromosome 16q24.1-qter by analyzing human/mouse somatic cell hybrids. |