| First Author | Goldman MB | Year | 1992 |
| Journal | Eur J Immunol | Volume | 22 |
| Issue | 12 | Pages | 3103-9 |
| PubMed ID | 1332870 | Mgi Jnum | J:3378 |
| Mgi Id | MGI:51891 | Doi | 10.1002/eji.1830221212 |
| Citation | Goldman MB, et al. (1992) T lymphocytes mediate immunologic control of C3 gene expression. Eur J Immunol 22(12):3103-9 |
| abstractText | Immunologic control of C3 gene expression by tissue macrophages can be accomplished by treatment of spleen fragments with anti-C3 antibody. We now demonstrate that suppression of C3 requires participation of T lymphocytes of both the CD4+ and CD8+ phenotypes. Pretreatment of splenic tissue with anti-Thy-1.2 monoclonal antibody blocks the ability of the anti-C3 antibody to induce C3 suppression. Reduction in either the CD4+ or CD8+ subpopulations of T lymphocytes also abrogates C3 suppression demonstrating that both T cell subsets are required in addition to the inducing antibody. Artificially elevating intracellular levels of cAMP with cholera toxin can partially substitute for the effects mediated by T cells in this reaction. Therefore, normal expression of the C3 gene can be suppressed by a regulatory network that requires the presence of a specific inducing antibody and T lymphocytes of both the CD4+ and CD8+ subsets. This regulatory network has many similarities to regulatory networks that have been well documented in suppression of specific murine immunoglobulin allotypes. |
