| First Author | Cieslak PR | Year | 1992 |
| Journal | J Exp Med | Volume | 176 |
| Issue | 6 | Pages | 1605-9 |
| PubMed ID | 1460420 | Mgi Jnum | J:3267 |
| Mgi Id | MGI:51780 | Doi | 10.1084/jem.176.6.1605 |
| Citation | Cieslak PR, et al. (1992) A severe combined immunodeficient (SCID) mouse model for infection with Entamoeba histolytica. J Exp Med 176(6):1605-9 |
| abstractText | We used severe combined immunodeficient (SCID) mice to study resistance to invasive infection with Entamoeba histolytica. Seven of seven SCID mice developed liver abscesses when challenged intrahepatically with virulent HM1:IMSS strain E. histolytica trophozoites. Only one of seven similarly challenged immunocompetent congenic C.B-17 mice developed an abscess. Adoptive transfer of polyclonal rabbit anti-E. histolytica antiserum, but not preimmune rabbit serum, completely protected 7 of 12 SCID mice from intrahepatic challenge with ameba. These results demonstrate that lymphocyte-based immunity is important in protection against amebic liver abscess, and that anti-E. histolytica antibody can protect against amebic infection in this system. The SCID mouse may provide a powerful model for studying the components of protective immunity to invasive amebiasis. |
