| First Author | Sener A | Year | 1993 |
| Journal | FEBS Lett | Volume | 316 |
| Issue | 3 | Pages | 224-7 |
| PubMed ID | 8422947 | Mgi Jnum | J:4021 |
| Mgi Id | MGI:52525 | Doi | 10.1016/0014-5793(93)81297-d |
| Citation | Sener A, et al. (1993) FAD-linked glycerophosphate dehydrogenase deficiency in pancreatic islets of mice with hereditary diabetes. FEBS Lett 316(3):224-7 |
| abstractText | The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase plays a key role in the glucose-sensing device of the insulin-producing pancreatic B-cell. Its activity was found to be decreased in islet, but not liver, homogenates of BL/Ks-db/db mice, in which diabetes mellitus represents an inherited disease. The decreased activity of FAD-linked glycerophosphate dehydrogenase contrasted with a normal activity of glutamate dehydrogenase and 2-ketoglutarate dehydrogenase in the islets of db/db mice. It is proposed that a site-specific defect of FAD-linked glycerophosphate dehydrogenase in the pancreatic B-cell might represent a far-from-uncommon causal or contributing factor in the pathogenesis of non-insulin-dependent diabetes mellitus. |
