| First Author | Watanabe M | Year | 1992 |
| Journal | Neuroreport | Volume | 3 |
| Issue | 12 | Pages | 1138-40 |
| PubMed ID | 1493227 | Mgi Jnum | J:28775 |
| Mgi Id | MGI:76315 | Doi | 10.1097/00001756-199212000-00027 |
| Citation | Watanabe M, et al. (1992) Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport 3(12):1138-40 |
| abstractText | In situ hybridization analyses have revealed drastic changes in expression and distribution of five subunit mRNAs of the mouse NMDA receptor channel during brain development. The epsilon 1 subunit mRNA is expressed postnatally and widely in the brain. On the other hand, the epsilon 2 subunit mRNA is found throughout the entire embryonic brain, but its expression becomes restricted to the forebrain at postnatal stages. The epsilon 3 subunit mRNA appears postnatally and predominantly in the cerebellum, whereas the epsilon 4 subunit mRNA is abundantly expressed in the diencephalon and the brainstem at embryonic and neonatal stages. In contrast, the zeta 1 subunit mRNA distributes ubiquitously in the brain throughout development. These findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development. |
