| First Author | Jänne OA | Year | 1993 |
| Journal | Ann Med | Volume | 25 |
| Issue | 1 | Pages | 83-9 |
| PubMed ID | 8435194 | Mgi Jnum | J:15793 |
| Mgi Id | MGI:63904 | Doi | 10.3109/07853899309147863 |
| Citation | Janne OA, et al. (1993) Androgen receptor and mechanism of androgen action. Ann Med 25(1):83-9 |
| abstractText | Androgen receptor is the intracellular protein that mediates biological actions of physiological androgens (testosterone and 5 alpha-dihydrotestosterone). Androgen receptor belongs to a large family of ligand-dependent proteins whose function is to modulate expression of genes and gene networks in a cell- and tissue-specific manner. The present overview describes the structurally important domains of the receptor protein, and discusses several aspects in the structure-function relationship, using naturally occurring receptor mutants in androgen insensitivity patients or experimental animals as examples. In addition, characteristics of androgen receptor expressed in a heterologous system are described, and their potential usefulness in specific molecular studies discussed. |
