| First Author | Sasada R | Year | 1993 |
| Journal | Biochem Biophys Res Commun | Volume | 190 |
| Issue | 3 | Pages | 1173-9 |
| PubMed ID | 8439318 | Mgi Jnum | J:3952 |
| Mgi Id | MGI:52457 | Doi | 10.1006/bbrc.1993.1173 |
| Citation | Sasada R, et al. (1993) Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. Biochem Biophys Res Commun 190(3):1173-9 |
| abstractText | Betacellulin (BTC) is a novel growth factor purified from the conditioned media of mouse pancreatic beta tumor cells and has been found to be a new member of the epidermal growth factor (EGF) family. The cDNA encoding human BTC has been cloned from a cDNA library prepared from human breast adenocarcinoma cell line MCF-7. The nucleotide sequence encodes a polypeptide which consists of 178 amino acid residues including a putative signal sequence, indicating that the structural organization of human BTC is similar to that of mouse BTC. The amino acid sequence of the human BTC precursor protein exhibits 79% similarity with that of the mouse precursor protein. The BTC gene was found to be expressed in several mouse tissues including kidney and liver as well as in a mouse beta tumor cell line and MCF-7 cells, suggesting that BTC might play a physiological role in normal tissues. |
