| First Author | Rehnmark S | Year | 1993 |
| Journal | FEBS Lett | Volume | 318 |
| Issue | 3 | Pages | 235-41 |
| PubMed ID | 8440378 | Mgi Jnum | J:4499 |
| Mgi Id | MGI:52988 | Doi | 10.1016/0014-5793(93)80519-z |
| Citation | Rehnmark S, et al. (1993) Differential adrenergic regulation of C/EBP alpha and C/EBP beta in brown adipose tissue. FEBS Lett 318(3):235-41 |
| abstractText | We investigated the regulation of the expression of two members of the C/EBP family of transcriptional activators, C/EBP alpha and C/EBP beta, in brown adipose tissue in mice. Less than one hour of cold exposure led to dramatic changes in the expression of both genes. C/EBP alpha steady-state mRNA and protein levels were drastically and rapidly reduced whereas C/EBP beta mRNA and protein levels were induced severalfold. Also norepinephrine injection affected the expression of the transcription factors. Preconfluent cells in brown fat primary cultures responded to norepinephrine with a decrease in C/EBP alpha and an increase in C/EBP beta mRNA; in confluent cells the expression of both factors was increased. Thus, C/EBP alpha and C/EBP beta gene expression is under adrenergic control both in vivo and in vitro but the type of response is directed by the degree of differentiation of the cells. |
