| First Author | Kalman B | Year | 1993 |
| Journal | J Neuroimmunol | Volume | 43 |
| Issue | 1-2 | Pages | 191-4 |
| PubMed ID | 7681448 | Mgi Jnum | J:12872 |
| Mgi Id | MGI:61089 | Doi | 10.1016/0165-5728(93)90091-c |
| Citation | Kalman B, et al. (1993) T cell receptor V beta gene utilization in myelin basic protein specific clones from CXJ1 recombinant inbred mice. J Neuroimmunol 43(1-2):191-4 |
| abstractText | CXJ1 mice are a recombinant inbred strain generated from experimental allergic encephalomyelitis (EAE) resistant BALB/c and EAE susceptible SJL/J progenitors. CXJ1 derive their major histocompatibility complex (MHC) class II and TCR genes from the BALB/c progenitor. However, their susceptibility to EAE is similar to SJL/J. Utilizing myelin basic protein (MBP)-specific CD4+ hybridoma clones and a MBP-specific T cell line (TCL) from CXJ1, we found the predominant T cell receptor (TCR) V beta chain expression to be V beta 8 and V beta 13. Our data support the concept of preferential, but not exclusive, TCR V beta usage in the MBP-specific response which is independent of MHC class II haplotype or immunodominant peptide. |
