| First Author | Prins JB | Year | 1993 |
| Journal | Science | Volume | 260 |
| Issue | 5108 | Pages | 695-8 |
| PubMed ID | 8480181 | Mgi Jnum | J:4756 |
| Mgi Id | MGI:53238 | Doi | 10.1126/science.8480181 |
| Citation | Prins JB, et al. (1993) Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice. Science 260(5108):695-8 |
| abstractText | A congenic, non-obese diabetic (NOD) mouse strain that contains a segment of chromosome 3 from the diabetes-resistant mouse strain B6.PL-Thy-1a was less susceptible to diabetes than NOD mice. A fully penetrant immunological defect also mapped to this segment, which encodes the high-affinity Fc receptor for immunoglobulin G (IgG), Fc gamma RI. The NOD Fcgr1 allele, which results in a deletion of the cytoplasmic tail, caused a 73 percent reduction in the turnover of cell surface receptor-antibody complexes. The development of congenic strains and the characterization of Mendelian traits that are specific to the disease phenotype demonstrate the feasibility of dissecting the pathophysiology of complex, non-Mendelian diseases. |
