| First Author | Delany AM | Year | 1993 |
| Journal | Arthritis Rheum | Volume | 36 |
| Issue | 7 | Pages | 983-93 |
| PubMed ID | 8318045 | Mgi Jnum | J:14499 |
| Mgi Id | MGI:62666 | Doi | 10.1002/art.1780360716 |
| Citation | Delany AM, et al. (1993) The synthetic retinoid (4-hydroxyphenyl)retinamide decreases collagen expression in vitro and in the tight-skin mouse. Arthritis Rheum 36(7):983-93 |
| abstractText | OBJECTIVE. We documented the effect of the retinoid (4-hydroxyphenyl)retinamide on collagen expression in a tissue culture and in an animal model of scleroderma. METHODS. We used RNA analysis, chloramphenicol acetyltransferase assays, organ culture, and histologic evaluation. RESULTS. We showed that (4-hydroxyphenyl)retinamide decreases alpha 1(I) collagen messenger RNA and transcription in cultured cells, and decreases collagen levels in the dermis of tight-skin mice. CONCLUSION. These results provide a basis for further experiments to address the efficacy of (4-hydroxyphenyl)retinamide in the treatment of scleroderma. |
