| First Author | Beauchamp GK | Year | 1993 |
| Journal | Physiol Behav | Volume | 54 |
| Issue | 1 | Pages | 179-84 |
| PubMed ID | 8327600 | Mgi Jnum | J:14148 |
| Mgi Id | MGI:62322 | Doi | 10.1016/0031-9384(93)90063-L |
| Citation | Beauchamp GK, et al. (1993) Strain differences in consumption of saline solutions by mice. Physiol Behav 54(1):179-84 |
| abstractText | Intake of saline (NaCl) solutions and water by males of two inbred strains of mice [C57BL/6J (C57) and 129/J] were examined using 48-h, two-bottle preference tests. There was a large strain difference in saline intake: at moderate concentrations (0.075-0.150 M) C57 mice tended to reject saline relative to water, whereas 129/J mice preferred it. Both strains of mice increased their intake of saline following lasix-induced sodium depletion and the preference exhibited by 129/J mice for 0.15 M NaCl was eliminated following LiCl toxicosis. The rejection of moderate concentrations of saline by C57 was shown to be due, in part at least, to prior exposure to iso- or hypertonic saline solutions: C57 mice that had no prior exposure to saline exhibited a greater intake of saline than C57 mice previously exposed to 0.30 M NaCl. Saline preferences of the 129/J mice were not affected by prior exposure to 0.30 M NaCl. Thus, the strain difference in mouse salt preference is due in part to postingestional consequences of saline consumption in C57 but not 129/J mice. |
