| First Author | Jacob CO | Year | 1993 |
| Journal | Nucleic Acids Res | Volume | 21 |
| Issue | 11 | Pages | 2761-6 |
| PubMed ID | 8332472 | Mgi Jnum | J:16089 |
| Mgi Id | MGI:64183 | Doi | 10.1093/nar/21.11.2761 |
| Citation | Jacob CO, et al. (1993) Disruption in the AU motif of the mouse TNF-alpha 3' UTR correlates with reduced TNF production by macrophages in vitro. Nucleic Acids Res 21(11):2761-6 |
| abstractText | Many cytokine mRNAs exhibit a conserved, AU-rich motif in the 3'-untranslated region (UTR) of the molecule. Such sequence elements have been implicated in the regulation of mRNA turnover and as potential translational regulators. We report on the identification of a 3 base pair insertion which disrupts the AU motif of the TNF-alpha gene in the NZW, B10.KPA44, SM/J and Mus spretus mice and an insertion of an 8 base pair sequence into the 3' AU motif of the IL-10 gene in the Mus Spretus mouse. The mutation in the AU motif of the TNF-alpha gene correlates with reduced production of this cytokine by peritoneal macrophages from these mouse strains. |
