| First Author | Tanaka T | Year | 1993 |
| Journal | Mutat Res | Volume | 288 |
| Issue | 2 | Pages | 277-80 |
| PubMed ID | 7688088 | Mgi Jnum | J:13298 |
| Mgi Id | MGI:61499 | Doi | 10.1016/0027-5107(93)90095-w |
| Citation | Tanaka T, et al. (1993) The scid mutation in mice causes defects in the repair system for both double-strand DNA breaks and DNA cross-links. Mutat Res 288(2):277-80 |
| abstractText | The sensitivity of scid fibroblasts established from C.B17-scid/scid fetuses to the DNA-damaging agents bleomycin, neocarzinostatin, mechlorethamine, mitomycin C, methyl methanesulfonate, and ultraviolet light, all of which induce different types of DNA damage, was examined. Scid fibroblasts were 2.8-, 3.7-, and 3.0-fold more sensitive to bleomycin, neocarzinostatin, and mechlorethamine, respectively, than wild-type fibroblasts derived from C.B17-+/+ fetuses. These findings indicate that the scid mutation in mice causes defects in repairing both double-strand DNA breaks and DNA cross-links. |
