| First Author | Warner B | Year | 1993 |
| Journal | Biochem Biophys Res Commun | Volume | 194 |
| Issue | 3 | Pages | 987-91 |
| PubMed ID | 8352812 | Mgi Jnum | J:14585 |
| Mgi Id | MGI:62749 | Doi | 10.1006/bbrc.1993.1918 |
| Citation | Warner B, et al. (1993) Prolactin-independent induction of alpha-lactalbumin gene expression in mammary gland explants from pregnant Balb/c mice. Biochem Biophys Res Commun 194(3):987-91 |
| abstractText | A four-fold increment of alpha-lactalbumin mRNA was induced in mammary gland explants from mid-pregnant Balb/c mice cultured for 24h in media containing insulin, cortisol and T3, and this response was enhanced by 40% with the addition of prolactin. In contrast, elevated beta-casein gene expression was evident only in explants cultured in media with insulin, cortisol, T3 and prolactin. These results suggest that the induction of the alpha-lactalbumin gene was prolactin-independent and did not result from retention of endogenous prolactin, or its effects, by the mammary explants. |
