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Publication : Characterization of a partial cDNA clone encoding porcine skeletal muscle titin: comparison with rabbit and mouse skeletal muscle titin sequences.

First Author  Fritz JD Year  1993
Journal  Comp Biochem Physiol B Volume  105
Issue  2 Pages  357-60
PubMed ID  8359022 Mgi Jnum  J:14388
Mgi Id  MGI:62557 Doi  10.1016/0305-0491(93)90241-v
Citation  Fritz JD, et al. (1993) Characterization of a partial cDNA clone encoding porcine skeletal muscle titin: comparison with rabbit and mouse skeletal muscle titin sequences. Comp Biochem Physiol B Biochem Mol Biol 105(2):357-60
abstractText  1. A cDNA fragment encoding 571 amino acid residues of porcine skeletal muscle titin was isolated from total RNA using RNA-PCR. 2. The porcine titin clone hybridized to a large RNA species (> 23 kb) in rabbit cardiac muscle, rabbit skeletal muscle and porcine skeletal muscle. 3. The porcine skeletal muscle titin clone encoded two types of 100-residue motifs and its amino acid sequence was 96% and 93% identical to the corresponding sequence of rabbit and mouse skeletal muscle titin, respectively. These results suggest that the titin sequence is highly conserved among mammalian species.
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