| First Author | Kim TA | Year | 1993 |
| Journal | Cancer Lett | Volume | 71 |
| Issue | 1-3 | Pages | 125-32 |
| PubMed ID | 8364887 | Mgi Jnum | J:21579 |
| Mgi Id | MGI:66680 | Doi | 10.1016/0304-3835(93)90107-k |
| Citation | Kim TA, et al. (1993) Transforming growth factor beta 1-induced delay of cell cycle progression and its association with growth-related gene expression in mouse fibroblasts. Cancer Lett 71(1-3):125-32 |
| abstractText | TGF beta-induced cell cycle progression is relatively slower than that induced by EGF or PDGF-BB. Further, TGF beta delays EGF or PDGF-induced 5-phase entry in C3H 10T1/2 mouse fibroblasts. In accordance with this delay, the induction of mRNA level of 'immediate early genes' such as c-myc, c-fos, c-jun and junB by TGF beta has slower kinetics compared with those of EGF. TGF beta induces c-sis gene, suggesting possible involvement of secondary growth stimulation by PDGF-like proteins. However, anti-PDGF-AB antibody, which was inhibitory to FDGF-BB-induced [3H]thymidine incorporation, did not block TGF beta-induced DNA synthesis. These results first demonstrate that the delay of cell cycle progression by TGF beta is closely associated with the altered regulation of growth-related gene expression in fibroblasts. |
