| First Author | Liu YX | Year | 1993 |
| Journal | Sci China B | Volume | 36 |
| Issue | 3 | Pages | 319-28 |
| PubMed ID | 8397803 | Mgi Jnum | J:16546 |
| Mgi Id | MGI:64619 | Citation | Liu YX, et al. (1993) Hormonal regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 gene expression in cultured mouse Sertoli cells. Sci China B 36(3):319-28 |
| abstractText | We have demonstrated for the first time that (i) mouse Sertoli cells predominantly secrete tPA under the action of FSH and cAMP-generating agents, whereas Leydig cells mainly produce uPA; (ii) Sertoli cells are also capable of secreting PAI-1, as well as FSH, growth factors and GnRH increase PAI-1 gene expression; (iii) the increases in tPA and PAI-1 activities by different hormones in the conditioned media of Sertoli cells correspond to the increases in the levels of tPA and PAI-1 mRNA in the cultured cells, suggesting that the synthesis of the activator-inhibitor in mouse Sertoli cells is regulated at a transcriptional level and the tPA secreted by Sertoli cells may be involved in the spermatogenesis. |
