| First Author | Wasco W | Year | 1993 |
| Journal | Nat Genet | Volume | 5 |
| Issue | 1 | Pages | 95-100 |
| PubMed ID | 8220435 | Mgi Jnum | J:27207 |
| Mgi Id | MGI:74626 | Doi | 10.1038/ng0993-95 |
| Citation | Wasco W, et al. (1993) Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet 5(1):95-100 |
| abstractText | Familial Alzheimer's disease (FAD) is a genetically heterogeneous disorder that includes a rare early-onset form linked to mutations in the amyloid b protein precursor (APP) gene. Clues to the function of APP derive from the recent finding that it is a member of a highly conserved protein family that includes the mammalian amyloid precursor-like protein (APLP1) gene which maps to the same general region of human chromosome 19 linked to late-onset FAD. Here we report the isolation of the human APLP2 gene. We show that APLP2 is a close relative of APP and exhibits a very similar pattern of expression in the brain and throughout the body. Like APP, APLP2 contains a cytoplasmic domain predicted to couple with the GTP-binding protein G(o) indicating that it may be an additional cell surface activator of this G protein. |
