| First Author | Dieli F | Year | 1993 |
| Journal | Eur J Immunol | Volume | 23 |
| Issue | 11 | Pages | 2897-902 |
| PubMed ID | 8223866 | Mgi Jnum | J:15689 |
| Mgi Id | MGI:63804 | Doi | 10.1002/eji.1830231125 |
| Citation | Dieli F, et al. (1993) Major histocompatibility complex regulation of interleukin-5 production in the mouse. Eur J Immunol 23(11):2897-902 |
| abstractText | Lymph node cells of CBA (H-2k), but not of BALB/c (H-2d) mice immunized epicutaneously with picryl chloride secrete interleukin (IL)-5 when stimulated with the specific antigen in vitro. The low IL-5 production in BALB/c mice persists when either picryl chloride or the unrelated antigen oxazolone are used, when the amount of antigen in vitro is varied and when a secondary response is studied. The difference in IL-5 production maps to the major histocompatibility complex (MHC) in the congenic BALB/b, BALB/c and BALB/k mice. Furthermore, lymph node cells from (k x d) F1 mice produce IL-5 when stimulated by antigen presented on H-2k but not on H-2d antigen-presenting cells. Finally, the low IL-5 production in vitro in BALB/c mice is correlated with low picryl-specific IgA levels in vivo, which otherwise are ten times greater in CBA and BALB/k mice. The influence of MHC on IL-5 production and IgA secretion in the mouse might be a possible basis for the association of MHC with IgA deficiency in humans. |
