| First Author | Burýsek L | Year | 1993 |
| Journal | FEBS Lett | Volume | 334 |
| Issue | 2 | Pages | 229-32 |
| PubMed ID | 8224251 | Mgi Jnum | J:15502 |
| Mgi Id | MGI:63622 | Doi | 10.1016/0014-5793(93)81717-e |
| Citation | Burysek L, et al. (1993) Expression of interleukin-1 alpha and interleukin-1 receptor type I genes in murine brown adipose tissue. FEBS Lett 334(2):229-32 |
| abstractText | At thermoneutral conditions, high steady-state levels of transcripts for both IL-1 alpha and its receptor IL-1RtI were found in specialized thermogenic organ, brown adipose tissue (BAT) of adult mice, as compared with the levels in lymph nodes, brain and spleen. A pronounced decrease of IL-1 alpha mRNA level in BAT was observed after lipopolysaccharide (LPS) administration and after exposure to cold. Likewise, LPS decreased the IL-1RtI mRNA level and depressed also the expression of cold-inducible genes for the BAT-specific heat-producing uncoupling protein and for lipoprotein lipase. It is concluded that, besides the centrally-mediated effects, there exists a direct peripheral interaction of IL-1 cytokines with BAT cells. |
