| First Author | Jacobsen FW | Year | 1993 |
| Journal | J Exp Med | Volume | 178 |
| Issue | 5 | Pages | 1777-82 |
| PubMed ID | 7693856 | Mgi Jnum | J:15284 |
| Mgi Id | MGI:63412 | Doi | 10.1084/jem.178.5.1777 |
| Citation | Jacobsen FW, et al. (1993) Novel role of interleukin 7 in myelopoiesis: stimulation of primitive murine hematopoietic progenitor cells. J Exp Med 178(5):1777-82 |
| abstractText | Interleukin 7 (IL-7) has been demonstrated to be an important regulator of the growth of B and T cell precursors as well as mature T cells, whereas IL-7 has been reported to have no direct myeloproliferative effects. Here we show that IL-7 potently and directly enhances colony stimulating factor-induced myeloid colony formation from Lin-Sca-1+ murine bone marrow progenitor cells, increasing the cloning frequency up to ninefold and cell numbers up to 50-fold, without affecting their ability to differentiate along the myeloid lineages In contrast, IL-7 has no effect on proliferation of committed Lin- myeloid progenitors. Thus, in addition to its established lymphopoietic potential, this study implicates a novel role of IL-7 in early myelopoiesis. |
