| First Author | Mathisen PM | Year | 1993 |
| Journal | Proc Natl Acad Sci U S A | Volume | 90 |
| Issue | 21 | Pages | 10125-9 |
| PubMed ID | 7694281 | Mgi Jnum | J:15845 |
| Mgi Id | MGI:63956 | Doi | 10.1073/pnas.90.21.10125 |
| Citation | Mathisen PM, et al. (1993) Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo. Proc Natl Acad Sci U S A 90(21):10125-9 |
| abstractText | We have identified a myelin basic protein (MBP) isoform in mouse embryos that includes an exon upstream of the usual transcription initiation site. This isoform, embryonic-neonatal MBP (E-MBP), is expressed at the protein level in the embryonic nervous system at a time when other MBP isoforms are not detected. In addition to the central and peripheral nervous systems of the embryo and neonate, the thymus, spleen, and testes also express E-MBP at the protein level. The expression of E-MBP in cell types distinct from the nervous system strongly suggests that this MBP isoform has a role apart from the formation of myelin. |
