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Publication : A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family.

First Author  Schwarz H Year  1993
Journal  Gene Volume  134
Issue  2 Pages  295-8
PubMed ID  8262389 Mgi Jnum  J:45110
Mgi Id  MGI:1101746 Doi  10.1016/0378-1119(93)90110-o
Citation  Schwarz H, et al. (1993) A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. Gene 134(2):295-8
abstractText  A 1.4-kb full-length cDNA was isolated from a library constructed from activated human T-cell leukemia virus type 1-transformed human T-lymphocytes. Sequence analysis identified this cDNA as a new member of the human nerve-growth-factor receptor/tumor-necrosis-factor receptor family and as the potential human homologue of the murine sequence, 4-1BB. The gene encodes three cysteine-rich motifs in the extracellular domain which are characteristic of this receptor family, a transmembrane region and a short N-terminal cytoplasmic portion which contains potential phosphorylation sites.
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