| First Author | Stepchenko AG | Year | 1994 |
| Journal | FEBS Lett | Volume | 337 |
| Issue | 2 | Pages | 175-8 |
| PubMed ID | 8287972 | Mgi Jnum | J:16379 |
| Mgi Id | MGI:64460 | Doi | 10.1016/0014-5793(94)80268-8 |
| Citation | Stepchenko AG (1994) Noncanonical Oct-sequences are targets for mouse Oct-2B transcription factor. FEBS Lett 337(2):175-8 |
| abstractText | We have suggested a random modification method for determining preferable binding sites of a DNA-binding protein and applied this method to the Oct-2B transcription factor. Our results indicate that the Oct-2B protein interacts with canonical oct sequence ATGC/TAAAT and degenerated sequences which contain TAAT motif in the binding site. We have determined nucleotides in the binding sites, involved in the DNA-protein interaction, and the equilibrium dissociation constants Kd for these sequences. These data show that a much greater number of potential targets for Oct proteins exist on DNA and changed our view on the gene expression regulation by this protein factor. |
