| First Author | Hughes S | Year | 1993 |
| Journal | Neurosci Lett | Volume | 163 |
| Issue | 2 | Pages | 205-7 |
| PubMed ID | 8309633 | Mgi Jnum | J:17155 |
| Mgi Id | MGI:65207 | Doi | 10.1016/0304-3940(93)90383-v |
| Citation | Hughes S, et al. (1993) Upregulation of the pro-opiomelanocortin gene in spinal motoneurones in muscular dystrophy in mice. Neurosci Lett 163(2):205-7 |
| abstractText | Pro-opiomelanocortin (POMC) mRNA was detected in motoneurones of mice using histochemical in situ hybridization and cDNA oligonucleotide probes for the adrenocorticotropin (ACTH) 4-11 and beta-endorphin 1-8 regions of POMC. Staining for POMC mRNA was negligible in motoneurones in normal adult mice but in dystrophic mice the mRNA was present in > 60% of the ventral horn cells. It is concluded that neuropathic change in motoneurones is accompanied by upregulation of the POMC gene and synthesis of POMC-derived peptides. |
