| First Author | Abed NS | Year | 1994 |
| Journal | Cell Immunol | Volume | 153 |
| Issue | 2 | Pages | 356-66 |
| PubMed ID | 8118869 | Mgi Jnum | J:16574 |
| Mgi Id | MGI:64643 | Doi | 10.1006/cimm.1994.1034 |
| Citation | Abed NS, et al. (1994) Interferon-gamma regulation of B lymphocyte differentiation: activation of B cells is a prerequisite for IFN-gamma-mediated inhibition of B cell differentiation. Cell Immunol 153(2):356-66 |
| abstractText | The Th1 and NK cell-derived cytokine interferon-gamma (IFN-gamma) influences both immune and inflammatory responses, and under some circumstances, IFN-gamma can inhibit B cell differentiation. We found that IFN-gamma inhibited LPS-induced IgM production in B cells by reducing the precursor frequency of IgM-secreting cells. This occurred without a significant decrease in B cell proliferation in response to either LPS or F(ab')2 anti-IgM. We also found that IFN-gamma inhibited IgM secretion, even when added as late as 48 hr after LPS stimulation. Small resting B cells were not affected by a pulse with IFN-gamma. However, a pulse of IFN-gamma inhibited the response of activated B cells to subsequent stimulation with LPS. Also, LPS upregulated expression of the IFN-gamma receptor on B cells. Our studies show that IFN-gamma targets stimulated but not resting B cells and suggest that IFN-gamma plays an important role in the normal homeostatic control of B cell polyclonal responses. |
