| First Author | Pfarr CM | Year | 1994 |
| Journal | Cell | Volume | 76 |
| Issue | 4 | Pages | 747-60 |
| PubMed ID | 8124713 | Mgi Jnum | J:17148 |
| Mgi Id | MGI:65200 | Doi | 10.1016/0092-8674(94)90513-4 |
| Citation | Pfarr CM, et al. (1994) Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras. Cell 76(4):747-60 |
| abstractText | As NIH 3T3 fibroblasts become quiescent, the level of c-Jun protein decreases while JunD accumulates. When resting cells are stimulated with fresh serum, nuclear-localized JunD is rapidly degraded, followed by resynthesis of both c-Jun and JunD later in G1. Overexpression of JunD results in slower growth and an increase in the percentage of cells in G0/G1 while c-Jun overexpression produces larger S/G2 and M phase populations. In addition, JunD partially suppresses transformation by an activated ras gene whereas c-Jun cooperates with ras to transform cells. These data indicate that two closely related transcription factors can function in an opposing manner. |
