| First Author | Crowe PD | Year | 1994 |
| Journal | Science | Volume | 264 |
| Issue | 5159 | Pages | 707-10 |
| PubMed ID | 8171323 | Mgi Jnum | J:18824 |
| Mgi Id | MGI:67055 | Doi | 10.1126/science.8171323 |
| Citation | Crowe PD, et al. (1994) A lymphotoxin-beta-specific receptor [see comments]. Science 264(5159):707-10 |
| abstractText | Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. The cell surface form of LT-alpha is assembled during biosynthesis as a heteromeric complex with lymphotoxin-beta (LT-beta), a type II transmembrane protein that is another member of the TNF ligand family. Secreted LT-alpha is a homotrimer that binds to distinct TNF receptors of 60 and 80 kilodaltons; however, these receptors do not recognize the major cell surface LT-alpha-LT-beta complex. A receptor specific for human LT-beta was identified, which suggests that cell surface LT may have functions that are distinct from those of secreted LT-alpha. |
