| First Author | Schneider JW | Year | 1994 |
| Journal | Science | Volume | 264 |
| Issue | 5164 | Pages | 1467-71 |
| PubMed ID | 8197461 | Mgi Jnum | J:18604 |
| Mgi Id | MGI:66866 | Doi | 10.1126/science.8197461 |
| Citation | Schneider JW, et al. (1994) Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science 264(5164):1467-71 |
| abstractText | The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb-/-) were induced by serum to re-enter the cell cycle. Development of the myogenic phenotype in Rb-/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-/- myotubes. |
