| First Author | Vidard L | Year | 1994 |
| Journal | Proc Natl Acad Sci U S A | Volume | 91 |
| Issue | 12 | Pages | 5627-31 |
| PubMed ID | 8202538 | Mgi Jnum | J:18748 |
| Mgi Id | MGI:66987 | Doi | 10.1073/pnas.91.12.5627 |
| Citation | Vidard L, et al. (1994) Specific T-cell tolerance may be preceded by a primary response. Proc Natl Acad Sci U S A 91(12):5627-31 |
| abstractText | We have evaluated the ability of ovalbumin to induce T-cell-specific tolerance in SJL mice. A significant decrease of interleukin 2 in lymph-node culture supernatants from tolerant mice upon antigen stimulation was seen. Oral tolerization was less effective than i.p.- or s.c.-tolerization protocols. Transfer experiments of either splenic or lymph-node T cells from tolerant mice to naive mice definitely ruled out suppression as a mechanism involved in tolerant mice. Surprisingly, we found that, before the establishment of specific T-cell tolerance to ovalbumin, T cells from mice that will display tolerance were responsive and synthesized interleukin 2 upon antigen challenge in vitro. Thus, we concluded that anergy cannot account solely for the T-cell unresponsiveness in tolerant mice. Furthermore, although we cannot rule out the hypothesis that the T-cell unresponsiveness in tolerant mice can be explained by programmed cell death of ovalbumin-specific T cells, these data led us to speculate that T-cell refractoriness could explain the drop of interleukin 2 production in lymph-node T-cell culture supernatant from tolerant mice. |
