| First Author | Friedman J | Year | 1994 |
| Journal | Am J Pathol | Volume | 144 |
| Issue | 6 | Pages | 1247-56 |
| PubMed ID | 8203464 | Mgi Jnum | J:18576 |
| Mgi Id | MGI:66839 | Citation | Friedman J, et al. (1994) An analysis of the expression of cyclophilin C reveals tissue restriction and an intriguing pattern in the mouse kidney. Am J Pathol 144(6):1247-56 |
| abstractText | Cyclophilin C (cyp C) is a cyclosporin A (CsA) binding protein originally isolated from a mouse bone marrow stromal cell line. We have compared the expression patterns of the mammalian cyclophilins A, B, and C in mouse tissues using in situ hybridization. These studies reveal that cyp C is expressed in a restricted subset of tissues including mouse ovary, testis, bone marrow, and kidney. Within the kidney, cyp C is highly expressed in a narrow zone in the outer medulla. Using monoclonal antibodies reactive against cyp C, we find that the kidney cells expressing cyp C correspond to the S3 segment of the nephron. The S3 segment has been shown to sustain histopathological damage from high dosages of CsA, raising the possibility that cyp C may be involved in mediating this damage. |
