| First Author | Vesque C | Year | 1993 |
| Journal | C R Seances Soc Biol Fil | Volume | 187 |
| Issue | 3 | Pages | 364-7 |
| PubMed ID | 8019912 | Mgi Jnum | J:21690 |
| Mgi Id | MGI:66485 | Citation | Vesque C, et al. (1993) [Molecular analysis of the development of the rhombencephalon]. C R Seances Soc Biol Fil 187(3):364-7 |
| abstractText | Hindbrain development involves a segmentation process which in particular governs cranial-motor nerves organization. We have initiated a molecular analysis of this morphogenetic process by searching for genes expressed in specific hindbrain segments (rhombomeres). We have identified a gene encoding a transcription factor, Krox-20, which is specific of rhombomeres 3 and 5 and several genes encoding receptor tyrosine kinases which are also segment-specific. The study of Krox-20 has allowed the identification of its nucleotide target, the localization of the functional domains of the protein and the demonstration of its involvement in the transcriptional activation of the Hoxb-2 gene and in the control of normal hindbrain development. |
