| First Author | Sims JE | Year | 1994 |
| Journal | Clin Immunol Immunopathol | Volume | 72 |
| Issue | 1 | Pages | 9-14 |
| PubMed ID | 8020198 | Mgi Jnum | J:18968 |
| Mgi Id | MGI:67200 | Doi | 10.1006/clin.1994.1100 |
| Citation | Sims JE, et al. (1994) The two interleukin-1 receptors play different roles in IL-1 actions. Clin Immunol Immunopathol 72(1):9-14 |
| abstractText | The proinflammatory cytokine interleukin-1 binds to two cell-surface receptors. The type I receptor, an 80-kDa protein with a cytoplasmic domain of approximately 215 amino acids, mediates the biological effects of IL-1. The type II receptor, a 60-kDa protein with 29 cytoplasmic amino acids, binds IL-1 and thereby prevents it from binding to the type I receptor but does not deliver a biological signal. Thus, the type II receptor acts as a negative regulator of IL-1 actions. It can do so either as a membrane-bound molecule or subsequent to shedding from the cell surface to generate a so-called soluble receptor. Both the naturally produced soluble type II receptor and the recombinantly generated soluble type I receptor are effective inhibitors of IL-1 action. The soluble type I receptor has shown efficacy in some preclinical models of inflammatory diseases, as well as in an initial clinical trial in a setting of cutaneous allergy. |
