First Author | Wang K | Year | 1994 |
Journal | Immunogenetics | Volume | 40 |
Issue | 2 | Pages | 116-22 |
PubMed ID | 8026860 | Mgi Jnum | J:19286 |
Mgi Id | MGI:67465 | Doi | 10.1007/BF00188174 |
Citation | Wang K, et al. (1994) Structural analysis of the mouse T-cell receptor Tcra V2 subfamily. Immunogenetics 40(2):116-22 |
abstractText | Cosmid clones containing T-cell receptor Tcra V2 subfamily gene segments have been isolated from a BALB/c cosmid library and subjected to DNA sequence analysis. The V gene segments in the Tcra V2 subfamily differ from each other by 3%-7% at the nucleotide level and 5%-16% at the amino acid level. T-cell receptor Tcra V2 gene segment polymorphisms have been identified in the B10.PL and PL/J mouse strains with a Tcra V2 subfamily-specific probe. These V gene segment polymorphisms may cause the differential Tcra V gene usage in induced experimental allergic encephalomyelitis between B10.PL and PL/J mice. |