| First Author | Fujita K | Year | 1994 |
| Journal | Immunobiology | Volume | 190 |
| Issue | 1-2 | Pages | 13-22 |
| PubMed ID | 8082881 | Mgi Jnum | J:18402 |
| Mgi Id | MGI:66690 | Doi | 10.1016/s0171-2985(11)80280-9 |
| Citation | Fujita K, et al. (1994) c-fos and jun gene expression in murine precursor B lymphocytes developed in the interleukin-7-dependent bone marrow cell culture. Immunobiology 190(1-2):13-22 |
| abstractText | We analyzed the expression of c-fos and jun family gene in murine pre-B cells developed in the interleukin-7-(IL-7) dependent bone marrow cell culture. The c-fos gene was expressed in the pre-B cells. The c-fos RNA became undetectable after IgM+ B cells were developed in the culture. The c-fos expression in the pre-B cells was IL-7-dependent. However, the c-fos RNA was not induced when the pre-B cells cultured without IL-7 for 6 h were restimulated with IL-7. The expression of c-jun RNA was slightly induced in the restimulated pre-B cells. The junB and junD RNA were the steady state level in the cells. These gene products formed AP-1 molecule in the pre-B cells. These results suggest that the AP-1 plays a role in the IL-7-dependent pre-B cell development. |
