| First Author | Bussemakers MJ | Year | 1994 |
| Journal | Biochem Biophys Res Commun | Volume | 203 |
| Issue | 2 | Pages | 1284-90 |
| PubMed ID | 8093045 | Mgi Jnum | J:20330 |
| Mgi Id | MGI:68428 | Doi | 10.1006/bbrc.1994.2321 |
| Citation | Bussemakers MJ, et al. (1994) Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter. Biochem Biophys Res Commun 203(2):1284-90 |
| abstractText | Decreased expression of the Ca(2+)-dependent cell adhesion molecule E-cadherin is observed in several poorly differentiated carcinomas and is presumably associated with an invasive phenotype of these tumors. Evidence accumulated so far indicates that decreased transcription is a major mechanism leading to defective E-cadherin function. Therefore, we isolated and characterized the human E-cadherin gene promoter and studied the transcriptional regulation of this gene in two human prostate cancer cell lines, one expressing E-cadherin (PC-3), the other one not expressing E-cadherin (TSU-pr1). We show that the E-cadherin promoter is not active in the non-expressing cells and that this may be due to the binding of a repressor protein to the promoter. |
