| First Author | Choi DS | Year | 1994 |
| Journal | FEBS Lett | Volume | 352 |
| Issue | 3 | Pages | 393-9 |
| PubMed ID | 7926008 | Mgi Jnum | J:39561 |
| Mgi Id | MGI:86842 | Doi | 10.1016/0014-5793(94)00968-6 |
| Citation | Choi DS, et al. (1994) The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Lett 352(3):393-9 |
| abstractText | The human serotonin 5-HT2B receptor, isolated from a human liver cDNA library, was transfected in COS-1 cells. Its pharmacological profile shows divergence with serotonin 5-HT2B receptors of other species. In particular, although strong correlation is observed between the human and the rat 5-HT2B receptor pharmacology, the correlation is almost as significant for the mouse 5-HT2B and the human 5-HT1D receptor agonists. The major sites of expression of its mRNA are in the human liver and kidney, with detectable expression in lung and heart. Therefore, this human 5-HT2B receptor could account for functions attributed to the peripheral 5-HT1D/5-HT2-like receptors, especially in the cardiovascular system. Thus, its detailed original pharmacology is of prime importance for therapeutic drug development. |
