| First Author | Libert C | Year | 1994 |
| Journal | J Exp Med | Volume | 180 |
| Issue | 4 | Pages | 1571-5 |
| PubMed ID | 7931089 | Mgi Jnum | J:20683 |
| Mgi Id | MGI:68758 | Doi | 10.1084/jem.180.4.1571 |
| Citation | Libert C, et al. (1994) Protection by alpha 1-acid glycoprotein against tumor necrosis factor-induced lethality. J Exp Med 180(4):1571-5 |
| abstractText | We here report that alpha 1-acid glycoprotein, a typical acute phase protein, protects mice from lethal shock induced by tumor necrosis factor (TNF) or endotoxin. The protection is observed both in normal and in galactosamine-sensitized mice. Optimal desensitization requires at least 3 mg alpha 1-acid glycoprotein administered 2 h before the lethal challenge. Under these conditions, complete inhibition of all TNF-induced metabolic changes was observed: fall in body temperature, release of liver transaminases, enhanced clotting time, and mortality. The known platelet aggregation-inhibitory activity of alpha 1-acid glycoprotein provides a possible explanation for this protective capacity. |
